Glutathione S-Transferase Polymorphisms and Risk of Differentiated Thyroid Carcinomas
نویسندگان
چکیده
منابع مشابه
Glutathione S-transferase polymorphisms and risk of differentiated thyroid carcinomas: a case-control analysis.
OBJECTIVE To determine the association between glutathione S-transferase (GST) polymorphisms and the risk of differentiated thyroid carcinoma (DTC) and benign thyroid tumors. DESIGN Case-control study. SETTING Tertiary care cancer center. PATIENTS Two hundred one patients with DTC, 103 patients with benign thyroid tumors, and 680 cancer-free control subjects. MAIN OUTCOME MEASURES Resul...
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BACKGROUND Isothiocyanates, compounds found primarily in cruciferous vegetables, have been shown in laboratory studies to possess anticarcinogenic activity. Glutathione S-transferases (GSTs) are involved in the metabolism and elimination of isothiocyanates; thus, genetic variations in these enzymes may affect in vivo bioavailability and the activity of isothiocyanates. OBJECTIVE The objective...
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Objective(s):To the best of our knowledge, this is the first report on the contributions of GST genetic variants to the risk of diabetic retinopathy in an Iranian population. Therefore, the objective of this study was to determine whether sequence variation in glutathione S-transferase gene (GSTM1 and GSTT1) is associated with development of diabetic retinopathy in type 2 diabetes mellitus (T2D...
متن کاملGlutathione S-transferase P1 Genetic Polymorphisms and Breast Cancer Risk.
PURPOSE To evaluate the potential association between the GSTP1 genotype and the development of breast cancer, a hospital based case-control study was conducted in South Korea. MATERIALS AND METGODS: The study population consisted of 171 histologically confirmed incidents of breast cancer cases, and 171 age-matched controls with no present, or previous, history of cancer. A PCR method was used ...
متن کاملGlutathione S-transferase polymorphisms and bone tumor risk in China.
AIM We aimed to study the potential role of GSTM1 and GSTT1 in the risk of osteosarcoma in Chinese population. METHODS We collected 110 osteosarcomas by pathologic examination and 226 controls from the First Affiliated Hospital of Harbin Medical University during December 2008 to December 2010. Genotyping was based upon duplex polymerase-chain-reaction with the PCR-CTPP method. RESULTS Indi...
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ژورنال
عنوان ژورنال: Archives of Otolaryngology–Head & Neck Surgery
سال: 2006
ISSN: 0886-4470
DOI: 10.1001/archotol.132.7.756